Depression Medication Choice


  • The choice of depression medications in primary care is difficult as there are many choices.
  • The best evidence does not indicate clear winners in terms of efficacy (recent AHRQ Synthesis).
  • The choice is then mostly across agents'  toxicity, burdens, and costs, issues patients care about.

Decision aids to be used during the encounter:

Online decision aid (English)


Paper-based decision aid:

English                                                    Spanish

English Full Set                                        Spanish Full Set

What you should know                            What you should know (Spanish)
Keep In Mind                                           Keep in Mind (Spanish)
Sleep                                                       Sleep (Spanish)
Cost                                                         Cost (Spanish)
Weight Changes                                      Weight Change (Spanish)
Sexual Issues                                          Sexual Issues (Spanish)
Stopping Approach                                  Stopping Approach (Spanish)


Additional resources:


DISCLAIMER:  No decision aid replaces the conversation patients should have with their clinicians to make important, clinical decisions.  Use of these decision aids carries no liability to its developers or to the Mayo Clinic Foundation for Education and Research.

If you download our decision aids, we would love to hear from you!  Please send us a note at to let us know who you are, why you are interested in the decision aid(s), and how you plan to use them.  Remember to check back to this page periodically to make sure you are using the most up-to-date version(s).

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