Cardiovascular Primary Prevention Choice

Statin/Aspirin Choice Decision Aid

The risk reductions attributed to statins and decision aids come from systematic reviews of randomized trials of primary prevention of coronary events with statins (25-30% reduction in risk of coronary events) and aspirin (15-20% reduction in coronary events).

The risk reduction in coronary events with fixed standard dose statins (atorvastatin 10 mg, simvastatin 40 mg, pravastatin 40 mg, rosuvastatin 5 mg) has been stable for years and was recently documented in a systematic review to be 25%, with high dose statins (2-3 times standard dose) adding about 15% relative risk reduction (i.e., 40% risk reduction).

Low-dose aspirin can reduce coronary events by about 20-25% and can impact the risk and outcomes of colon cancer and other cancers.


Risk calculators:  

Decision aids to be used during the encounter:

Decision aids in practice:  

Additional resources:


DISCLAIMER:  No decision aid replaces the conversation patients should have with their clinicians to make important, clinical decisions.  Use of these decision aids carries no liability to its developers or to the Mayo Clinic Foundation for Education and Research.

If you download our decision aids, we would love to hear from you!  Please send us a note at to let us know who you are, why you are interested in the decision aid(s), and how you plan to use them.  Remember to check back to this page periodically to make sure you are using the most up-to-date version(s).

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